METHOD FOR PREPARING IMPROVED CARDIOMYCOCYTE-LIKE CELLS
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United States of America Patent
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Issued Date -
Nov 13, 2014
app pub date -
Dec 6, 2012
filing date -
Dec 6, 2011
priority date (Note) -
Abandoned
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Abstract
The present invention relates to the field of cell differentiation. In particular, the present invention relates to a method for preparing improved cardiomyocyte-like cells differentiated from at least one multipotent or pluripotent cell, comprising a step of contacting the cardiomyocyte-like cell(s) with at least one agent to promote and/or induce integrin subunit alpha-V (integrin αv) activity, thereby modulating expression of at least one cardiac gene of said cardiomyocyte-like cells. It also relates to a method for screening for an agent capable of improving cardiomyocytes differentiated from at least one multipotent or pluripotent cell.
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