Importance

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Abstract

A first or second polypeptide for use in a method of treating or preventing a disorder by tolerisation, wherein said method comprises administration of the first and second polypeptide; and wherein both first and second polypeptides:

i) are of 7 to 30 amino acids in length;ii) comprise at least one MHC Class II-binding T cell epitope; andiii) are a fragment of a protein allergen or a homologous variant of said fragment;wherein said first polypeptide induces the release of an amount of IL-10 that is greater than the amount of IL-10 released in response to the whole protein allergen from which the first polypeptide derives;wherein said disorder is characterised by an inappropriate immune response to the protein allergen from which the second polypeptide derives.

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First Claim