TOX3 AS A BIOMARKER FOR BREAST CANCER
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United States of America Patent
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Issued Date -
Oct 30, 2014
app pub date -
May 21, 2014
filing date -
Dec 4, 2009
priority date (Note) -
Abandoned
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Abstract
The invention provides compositions and methods for detecting and/or modulating TOX3 gene expression and/or biological activity. Such compositions and methods find utility in the detection and/or treatment of certain subsets of cancers, e.g. breast cancer. In particular, the inventive compositions and methods are drawn to production and use of anti-TOX3 antibodies and TOX3 nucleic acids for both detection and modulation of TOX3. The invention also provides for pharmaceutical compositions and methods for the modulation of TOX3 in a subject in need thereof. Further aspects of the invention relate to transgenic mice that either overexpress or inducibly express TOX3.
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