STABILIZATION OF X-RAY DIAGNOSTIC COMPOSITION
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United States of America Patent
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Issued Date -
Oct 30, 2014
app pub date -
Dec 20, 2012
filing date -
Dec 21, 2011
priority date (Note) -
Abandoned
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Abstract
The invention relates to a composition comprising a non-ionic X-ray contrast agent in a pharmaceutically acceptable carrier, and particularly to a supersaturated X-ray composition comprising X-ray contrast agents with a high dissolution temperature in water. Particularly, the invention provides such composition which is stable, and wherein crystallisation during storage is avoided. In a preferred aspect the X-ray contrast agent is Ioforminol and the composition includes a nucleation- and growth inhibitor. The invention further relates to a process for the preparation of such stable diagnostic X-ray composition.
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