ASSESSMENT OF PML RISK AND METHODS BASED THEREON
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United States of America Patent
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Oct 23, 2014
app pub date -
Oct 16, 2012
filing date -
Mar 7, 2012
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The invention provides a method of assessing the risk of occurrence of progressive multifocal leukoencephalopathy (PML) in a subject as well as a method of stratifying a subject undergoing α4-integrin and/or VLA-4 blocking agent treatment for suspension of the treatment and a method of stratifying a subject undergoing Highly Active Antiretroviral Therapy (HAART) for alteration of HAART. These methods comprise detecting the level of P-selectin glycoprotein ligand-1 (PSGL-1) expressing T cells in a sample from the subject.
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