ORAL COMPLEX FORMULATION COMPRISING OMEGA-3 FATTY ACID AND HMG-COA REDUCTASE INHIBITOR WITH IMPROVED STABILITY
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Oct 23, 2014
app pub date -
Nov 16, 2012
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Nov 17, 2011
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Abstract
The present invention relates to an oral complex formulation comprising omega-3 fatty acid or its derivatives encapsulated in a hard or soft capsule containing sorbitol and sorbitan, as well as an HMG-CoA reductase inhibitor. The formulation of the present invention comprising omega-3 fatty acid encapsulated with sorbitol and sorbitan provides better prevention related materials from being formed, leading to improved long-term storage stability. The oral complex formulation of the present invention also can raise the serum HDL-cholesterol level, while reducing both LDL-cholesterol and TG levels. The oral complex formulation of the present invention is useful for treatment of hyperlipidemia.
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