Compositions Using Antibodies Directed to GPNMB and Uses Thereof
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United States of America Patent
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app pub date -
Jul 1, 2014
filing date -
Aug 20, 2008
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Abstract
The present invention relates to antibodies, including fully human monoclonal antibodies, with specificity to GPNMB, and uses of such antibodies. The present invention further provides compositions that increase expression of GPNMB on the surface of tumor cells, and methods of using such compositions to increase the anti-cancer activity or other therapeutic efficacy of the antibodies and immunoconjugates provided herein.
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