MCAM ANTAGONISTS AND METHODS OF TREATMENT
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United States of America Patent
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Issued Date -
Oct 23, 2014
app pub date -
Jun 6, 2012
filing date -
Jun 6, 2011
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Abstract
Described herein are MCAM antagonists, including MCAM antagonist antibodies capable of inhibiting the interaction between MCAM and it ligand, a laminin α4 chain, e.g., an α4 chain of laminin 411. These MCAM antagonists, e.g., anti-MCAM antibodies, may be useful to treat neuroinflammatory conditions, for example, multiple sclerosis and Parkinson's disease, by inhibiting the infiltration of MCAM-expressing cells into the central nervous system (CNS), e.g., extravasation of TH17 cells into the CNS.
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