Ex Vivo Expansion of Human Hematopoietic Stem Cells
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United States of America Patent
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Issued Date -
Oct 16, 2014
app pub date -
Nov 12, 2013
filing date -
May 4, 2007
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Abandoned
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Abstract
Methods and kits for expanding the number of hematopoietic stem cells are provided. The methods comprise incubating cells in medium comprising isolated IGFBP-2 and an angiopoietin-like protein (Angptl). Expanded HSCs are provided as well as culture media and kits for the expansion of human HSCs in a defined medium. Methods of administering expanded human HSCs to and individual are provided as well as methods of treating an individual by administering certain growth factors and cytokines.
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