Cyclin Based Inhibitors of CDK2 and CDK4
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United States of America Patent
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Jul 12, 2013
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Mar 27, 2013
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Abstract
Structural and functional analysis of peptide inhibitor binding to the cyclin D and cyclin A groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation.
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