Method for preparing physiologically active polypeptide complex

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United States of America Patent

PATENT NO 11434271
APP PUB NO 20140296475A1
SERIAL NO

14356054

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Abstract

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A method for preparing a conjugate of a physiologically active polypeptide and a non-peptide polymer by linking physiologically active polypeptide with non-peptide polymer through a covalent bond using an organic solvent is provided. A method for preparing a physiologically active polypeptide complex by linking the conjugate with a carrier is provided. The complex shows improved in vivo duration and stability of the physiologically active polypeptide. The method can prepare the conjugate at a lower production cost, and the resulting conjugate shows an extension of in vivo activity at a relatively high level and significantly increase in the blood half-life.

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Patent Owner(s)

Patent OwnerAddress
HANMI SCIENCE CO LTD214 MUHA-RO PALTAN-MYEON GYEONGGI-DO HWASEONG-SI 18536

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Choi, Jae Hyuk Seoul, KR 60 328
Jang, Myung Hyun Seoul, KR 19 137
Kim, Dae Jin Hwaseong-si, KR 95 825
Kim, Seung Su Seoul, KR 25 142
Kwon, Se Chang Seoul, KR 120 1146
Lee, Jong Soo Seongnam-si, KR 85 376

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