PYRIMIDO[4,5-D]PYRIMIDINYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

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United States of America Patent

APP PUB NO 20140296216A1
SERIAL NO

14125304

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Abstract

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A compound of formula (I) or (II) and use of the compound in the preparation of drugs for treating cancer are disclosed. The study shows that the compounds can inhibit the growth of many kinds of tumor cells, can be used for targeting epidermal growth factor receptor (EGFR), and particularly can inhibit tumor cells with single or multiple mutations of EGFR (T790M). Therefore, the compound can be used as EGFR inhibitor to treat cancer and has a relatively large application value.

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Patent Owner(s)

Patent OwnerAddress
GUANGZHOU INSTITUTE OF BIOMEDICINE AND HEALTH CHINESE ACADEMY OF SCIENCESGUANGZHOU GUANGDONG 510530

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chang, Shaohua Guangdong, CN 4 10
Chen, Yi Shanghai, CN 458 3558
Ding, Jian Shanghai, CN 199 1944
Ding, Ke Guangdong, CN 83 511
Geng, Meiyu Shanghai, CN 54 68
Tu, Zhengchao Guangdong, CN 14 29
Xu, Shilin Guangdong, CN 9 13
Zhang, Lianwen Guangdong, CN 1 9

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