APOAEQUORIN FOR REDUCING NEURONAL INJURY DUE TO ISCHEMIA
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United States of America Patent
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Oct 2, 2014
app pub date -
Nov 15, 2012
filing date -
Nov 15, 2011
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The present invention provides apoaequorin-based compositions and methods for preconditioning neurons in a subject to reduce neuronal injury due to brain ischemia. Methods include the step of administering apoaequorin to neurons in a subject, wherein the apoaequorin initiates a change in cytokine expression levels resulting in a reduction of neuronal injury due to brain ischemia as compared to neurons not administered the apoaequorin. Various formulations, including injectable dosages, are described.
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