AMATOXIN-CONJUGATES WITH IMPROVED LINKAGES
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United States of America Patent
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app pub date -
Mar 9, 2012
filing date -
Mar 10, 2011
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Abstract
The invention relates to tumor therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by certain linkages, which are useful in the treatment of cancer. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.
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