MULTIFUNCTIONALIZED MATERIALS
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United States of America Patent
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Issued Date -
Sep 18, 2014
app pub date -
May 4, 2012
filing date -
May 5, 2011
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Abandoned
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Abstract
The present invention describes a method for producing multifunctional materials comprising the steps of: a) chemically activating functional groups present in a micro- or nanoparticulate base material; b) performing a nucleophilic substitution reaction between at least one terminal amino, carboxyl or thiol group of a PNA or DNA type A chain and at least one activated functional group of the base material produced in step (a); c) conjugating to a biomolecule by means of chemically activating functional groups of a PNA/DNA type B chain, which is complementary to the PNA/DNA type A chain; and d) hybridizing the PNA/DNA type A chains which are bound to the base material according to step b) and the PNA/DNA type B chains having biomolecules bound thereto according to step c) by means of PNA-PNA or PNA-DNA molecular recognition.
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