Methods of depleting antibodies directed towards major histocompatibility complex
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United States of America Patent
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Issued Date -
Sep 18, 2014
app pub date -
Oct 4, 2013
filing date -
Mar 17, 2000
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Abandoned
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Abstract
The invention provides a method of depleting anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants, derivatives or fragments thereof and removing at least the recombinant MHC molecules to which antibodies to said recombinant MHC molecules contained within the sample have bound. This method allows the depletion of one or more specific MHC particularly HLA allele antibodies from a sample.
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