MODIFIED DOCETAXEL LIPOSOME FORMULATIONS
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United States of America Patent
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Sep 18, 2014
app pub date -
Mar 13, 2014
filing date -
Mar 13, 2013
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Abstract
The present invention provides compositions for the treatment of cancer. The compositions include liposomes containing a phosphatidylcholine lipid, a sterol, a PEG-lipid, and a taxane. The PEG-lipid constitutes from about 2 to about 8 mol % of the lipids in the liposome. The taxane is docetaxel esterified at the 2′-O position with a heterocyclyl-(C2-5alkanoic acid). Methods for preparation of liposomal taxanes and treatment of cancer with liposomal taxanes are also disclosed.
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