Spray-dried pharmaceutical compositions comprising active agent nanoparticles
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United States of America Patent
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Jun 30, 2020
Grant Date -
Sep 4, 2014
app pub date -
Mar 3, 2014
filing date -
Mar 4, 2013
priority date (Note) -
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Abstract
Provided herein are dry pharmaceutical compositions for transmucosal delivery, comprising spray-dried particles that include pharmaceutically active agent nanoparticles, a binder, and a pharmaceutically acceptable carrier, where the active agent nanoparticles have an average particle size diameter prior to spray-drying of less than about 1 μm, and wherein up to 10% of the spray-dried particles have a particle size of less than 10 μm; at least 50% of the spray-dried particles have a particle size of at least about 15 μm; and at least 90% of the spray-dried particles have a particle size of up to about 55 μm. Also provided are methods for making such pharmaceutical compositions and therapeutic methods comprising transmucosally administering the compositions, such as intranasally or intravaginally.
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