Volatile Compound Fingerprint Atlas-Spectrum Model Used for Early Gastric Cancer Diagnosis/ Warning
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United States of America Patent
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Issued Date -
Aug 28, 2014
app pub date -
Jan 17, 2012
filing date -
Nov 16, 2011
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Abandoned
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Abstract
Volatile organic compounds emitted from gastric cancer cell metabolite is separated and detected using HS-SPME/GC-MS. A volatile compounds fingerprint atlas-spectrum model are disclosed for early gastric cancer diagnosis/warning Volatiles 3-octanone and 2-butanone as indicators of gastric cancer cells which are not contained in the headspace of gastric mucosal cells GES-1. Meanwhile, the ratio of mass to volume to concentration of 4-isopropoxy alcohol, nonanoic acid, and 4-butoxy n-butanol is as follows: 4-isopropoxy alcohol [gastric cancer cells]/[normal gastric mucosa cells]≦0.31; nonanoic acid [gastric cancer cells]/[normal gastric mucosa cells]≦0.36; and 4-butoxy n-butanol [gastric cancer cells]/[normal gastric mucosa cells]≦0.40. The volatile organic compound in cell metabolite to be detected is compared with the fingerprint atlas-spectrum model, so as to implement screening and warning of the early gastric cancer.
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