Polymeric Hyperbranched Carrier-Linked Prodrugs
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United States of America Patent
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Aug 28, 2014
app pub date -
Aug 10, 2012
filing date -
Aug 12, 2011
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Abstract
The present invention relates to water-soluble carrier-linked prodrugs of formula (I), wherein POL is a polymeric moiety, each Hyp is independently a hyperbranched moiety, each moiety SP is independently a spacer moiety, each L is independently a reversible prodrug linker moiety, m is 0 or 1, each n is independently an integer from 2 to 200 and each x is independently 0 or 1. It further relates to pharmaceutical compositions comprising said water-soluble carrier-linked prodrugs and methods of treatment.
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