PROBE FOR iFRET AND USE THEREOF
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United States of America Patent
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Issued Date -
Aug 28, 2014
app pub date -
Jun 25, 2012
filing date -
Jun 23, 2011
priority date (Note) -
Published
status (Latency Note)
Importance
Abstract
The present invention relates to a probe for iFRET and use thereof. Specifically, the present invention relates to a novel probe for iFRET, a method for preparing the probe for iFRET, a method for searching a target protein-specific binding site or a molecule having the binding site using the probe for iFRET, and a method for imaging the target protein using the probe for iFRET. The probe for iFRET according to the present invention utilizes an amino acid in a protein as a fluorescent donor, unlike the conventional FRET method. Therefore, only one fluorescent material is used, and its emission wavelength is distinct from the intrinsic fluorescence of the protein. Thus, high specificity and sensitivity are ensured, and the quantity, activity and mechanism of various proteins can be analyzed in an easy and accurate manner.
First Claim
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