NANOPARTICLES FOR CONTROLLING BLEEDING AND DRUG DELIVERY
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United States of America Patent
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Issued Date -
Aug 28, 2014
app pub date -
Oct 12, 2012
filing date -
Oct 13, 2011
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Abstract
A temperature stable nanoparticle is provided comprising a core, a water soluble polymer and a peptide, the water soluble polymer attached to the core at a first terminus of the water soluble polymer, the peptide attached to a second terminus of the water soluble polymer, the peptide comprising an RGD amino acid sequence, the water soluble polymer of having sufficient length to allow binding of the peptide to glycoprotein lib/Ilia (GPIIb/llla). In one aspect, the nanoparticle has a melting temperature over 35° C. In various aspects, the nanoparticle has a spheroid shape and a diameter of less than 1 micron.
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