Immunologic Constructs and Methods
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United States of America Patent
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Issued Date -
Aug 21, 2014
app pub date -
Apr 29, 2014
filing date -
Nov 4, 2011
priority date (Note) -
Abandoned
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Abstract
The present invention relates to improved vaccines and the design and making of such vaccines that enhance immunogenicity of the vaccine and/or reduce reactogenicity to the vaccine when administered. In particular the vaccines and immunogenic compositions of the present invention relate to flagellin-antigen fusion proteins in which the spatial orientation of the flagellin to antigen and the charge distribution of the antigen is optimized to enhance immunogenicity and/or reduce reactogenicity and/or improve folding of the protein.
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