COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION
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United States of America Patent
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Issued Date -
Aug 21, 2014
app pub date -
May 10, 2012
filing date -
May 17, 2011
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Abstract
Compounds, pharmaceutical compositions, and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by JAMM proteins are disclosed. The compounds and compositions inhibit the enzymatic activity of a JAMM domain, including the JAMM domain of the CSN5 subunit of the COP9-signalsome (CSN), the JAMM domain of the Rpn11/Poh1/Psmd14 subunit of the 26S proteasome, the JAMM domain of AMSH, the JAMM domain of AMSH-LP, the JAMM domain of BRCC36, among other JAMM domains.
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