SYNTHETIC SINGLE CHAIN VARIABLE DOMAIN (SCFV) IMMUNOGLOBULIN FRAGMENT VEHICLE CONTAINING FUSION PROTEINS FOR TARGETED INTRODUCTION OF siRNA
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
N/A
Issued Date -
Aug 21, 2014
app pub date -
Nov 5, 2013
filing date -
Nov 5, 2012
priority date (Note) -
Abandoned
status (Latency Note)
Importance
Abstract
A fusion protein and process are provided by which double-stranded RNA containing small interfering RNA nucleotide sequences is introduced into specific cells and tissues. A cell surface receptor specific synthetic single chain variable domain (scFv) immunoglobulin fragment vehicle specific to a cell surface receptor of the cell and having a cell surface receptor specific binding site is provided. An RNA binding protein fused to said scFv is adsorbed with a double-stranded RNA or to a small hairpin RNA sequence complementary to a nucleotide sequence of a target gene in the cell and includes a small interfering RNA operative to suppress production of a target cellular protein. The scFv induces internalization into said cell of the fusion protein subsequent to the binding of said scFV to the cell surface receptor of the target cell.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully