PROPHYLACTIC AND THERAPEUTIC AGENT FOR NEUROLOGICAL DISEASES USING LIPOPROTEINS AND PROPHYLACTIC AND THERAPEUTIC METHOD FOR NEUROLOGICAL DISEASES
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United States of America Patent
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Issued Date -
Aug 14, 2014
app pub date -
Sep 19, 2012
filing date -
Sep 20, 2011
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Abstract
The present invention provides an agent for neurological disease, the agent comprising lipoprotein containing apolipoprotein E as the active substance thereof, in which a neuroprotective system via activation of neuroprotective molecules and/or the inactivation of neurodegeneration-inducing molecules, mediated by lipoprotein receptors, may work as a mechanism, and a prophylactic and therapeutic method for neurological diseases. The lipoproteins containing apolipoprotein E and/or neuroprotective system through, as the action mechanism, the activation of neuroprotective molecules and the inactivation of neurodegeneration-inducing molecules that are mediated by lipoprotein receptors have prophylactic and therapeutic effects of, including, inhibiting nerve cell apoptosis, on neurological disease such as various neurodegenerative diseases accompanied by nerve cell apoptosis as the essential condition. The invention provides the agent comprising apolipoprotein E-containing lipoproteins and/or having an action mechanism through the activation of neuroprotective molecules and the inactivation of neurodegeneration-inducing molecules that are mediated by lipoprotein receptors.
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