Method for assessing progression of clinical state of malignant neoplasm by quantitative detection of DNA in blood
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United States of America Patent
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N/A
Issued Date -
Aug 14, 2014
app pub date -
May 16, 2012
filing date -
May 16, 2011
priority date (Note) -
Published
status (Latency Note)
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Abstract
The object of the invention is to provide a method for quantitatively assessing the degree of progression of a malignant neoplasm in a patient who has been medicated. Provided is a method for assessing the progression of the clinical state of a malignant neoplasm in a subject who has been administered with a medicine for treating the malignant neoplasm, the method being characterized by comprising: (1) a step of determining the ratio of DNA molecules having an activation mutation that serves as an activation marker for the medicine to DNA molecules having a normal marker gene in DNA in the blood from the subject; (2) a step of determining the ratio of DNA molecules having a resistance mutation that serves as a resistance marker for the medicine to DNA molecules having a normal marker gene in the DNA in the blood from the subject; and (3) a step of comparing a value obtained in the step (2) with a value obtained in the step (1) to thereby assess whether or not the malignant neoplasm in the subject has acquired resistance to the treatment with the medicine.
First Claim
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Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
DNA CHIP RESEARCH INC | TOKYO 1050022 |
International Classification(s)

- 2012 Application Filing Year
- C12Q Class
- 2418 Applications Filed
- 1732 Patents Issued To-Date
- 71.63 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Imamura, Fumio | Osaka-shi, JP | 4 | 140 |
# of filed Patents : 4 Total Citations : 140 | |||
Kato, Kikuya | Osaka-shi, JP | 8 | 245 |
# of filed Patents : 8 Total Citations : 245 | |||
Kumagai, Toru | Osaka-shi, JP | 24 | 314 |
# of filed Patents : 24 Total Citations : 314 | |||
Nishino, Kazumi | Osaka-shi, JP | 2 | 119 |
# of filed Patents : 2 Total Citations : 119 | |||
Taniguchi, Kazuya | Osaka-shi, JP | 30 | 300 |
# of filed Patents : 30 Total Citations : 300 | |||
Uchida, Junji | Osaka-shi, JP | 9 | 241 |
# of filed Patents : 9 Total Citations : 241 |
Cited Art Landscape
- No Cited Art to Display

Patent Citation Ranking
- 108 Citation Count
- C12Q Class
- 99.37 % this patent is cited more than
- 11 Age
Forward Cite Landscape
- No Forward Cites to Display

Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
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11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Feb 14, 2026 |
Fee | Large entity fee | small entity fee | micro entity fee |
---|---|---|---|
Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
Full Text

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Oct 11, 2011 | AS | ASSIGNMENT | free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:CHRISTIE, BRUCE A.;KOSMYNINE, ALEXEI N.;PETERSON, EDWARD W.;AND OTHERS;SIGNING DATES FROM 20101025 TO 20111010;REEL/FRAME:027062/0387 Owner name: ACUFOCUS, INC., CALIFORNIA |
Feb 17, 2011 | P | Published | |
Aug 13, 2010 | F | Filing | |
Aug 13, 2009 | PD | Priority Date |

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