Method for assessing progression of clinical state of malignant neoplasm by quantitative detection of DNA in blood

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United States of America Patent

APP PUB NO 20140227706A1
SERIAL NO

14118098

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The object of the invention is to provide a method for quantitatively assessing the degree of progression of a malignant neoplasm in a patient who has been medicated. Provided is a method for assessing the progression of the clinical state of a malignant neoplasm in a subject who has been administered with a medicine for treating the malignant neoplasm, the method being characterized by comprising: (1) a step of determining the ratio of DNA molecules having an activation mutation that serves as an activation marker for the medicine to DNA molecules having a normal marker gene in DNA in the blood from the subject; (2) a step of determining the ratio of DNA molecules having a resistance mutation that serves as a resistance marker for the medicine to DNA molecules having a normal marker gene in the DNA in the blood from the subject; and (3) a step of comparing a value obtained in the step (2) with a value obtained in the step (1) to thereby assess whether or not the malignant neoplasm in the subject has acquired resistance to the treatment with the medicine.

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Patent OwnerAddress
DNA CHIP RESEARCH INCTOKYO 1050022

International Classification(s)

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  • 2012 Application Filing Year
  • C12Q Class
  • 2418 Applications Filed
  • 1732 Patents Issued To-Date
  • 71.63 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201220132014201520162017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Imamura, Fumio Osaka-shi, JP 4 140
Kato, Kikuya Osaka-shi, JP 8 245
Kumagai, Toru Osaka-shi, JP 24 314
Nishino, Kazumi Osaka-shi, JP 2 119
Taniguchi, Kazuya Osaka-shi, JP 30 300
Uchida, Junji Osaka-shi, JP 9 241

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  • 108 Citation Count
  • C12Q Class
  • 99.37 % this patent is cited more than
  • 11 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges4351109245109624427148841301 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +05010015020025030035040045050055060065070075080085090095010001050110011501200

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