PLATELET ADP RECEPTOR INHIBITORS

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United States of America Patent

SERIAL NO

13956251

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Abstract

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Novel compounds of formulae (I) to (VII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylfulfonamide derivatives which are effective platelet ADF receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I) to (VIII), or a pharmaceutically acceptable salt thereof.

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Patent Owner(s)

Patent OwnerAddress
ALEXION PHARMACEUTICALS INC121 SEAPORT BOULEVARD BOSTON MA 02210

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huang, Wolin Foster City, US 39 444
Jantzen, Hans-Michael San Francisco, US 14 49
Kane-MaGuire, Kim A Belmont, US 7 25
Marlowe, Charles K Redwood City, US 35 403
Scarborough, Robert M Half Moon Bay, US 183 2713
Sedlock, David M Burlingame, US 10 127

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