BIOMARKER ALGORITHM FOR DETERMINING THE TIME OF STROKE SYMPTOM ONSET AND METHOD
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United States of America Patent
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Issued Date -
Aug 7, 2014
app pub date -
Jan 29, 2014
filing date -
Feb 1, 2013
priority date (Note) -
Abandoned
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Abstract
A method of determining the time of stroke symptom onset is provided including obtaining a biological sample from an individual; contacting the biological sample with a detection composition comprising at least one expression mediator of a LY96, ARG1, CA4, and a TLR expression mediators, or a combination of these expression mediators, wherein at least one of the expression mediators is associated with an acute phase response of ischemic stroke, for forming a detectable response; and correlating the detectable response with a time of onset of one or more stroke symptoms. A composition is provided having a nucleic acid probe, an antibody, or a purified biomarker that is specific for at least one of a LY96, ARG1, CA4, and TLR expression mediators, or a combination of these expression mediators.
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