Recombinant butyrylcholinesterases and truncates thereof
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United States of America Patent
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Feb 10, 2015
Grant Date -
Aug 7, 2014
app pub date -
Apr 3, 2014
filing date -
Dec 21, 2009
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Abstract
Isolated nucleic acids encoding polypeptides that exhibit butyrylcholinesterase (BChE) enzyme activity are disclosed, along with molecular criteria for preparing such nucleic acids, including codon optimization. Methods of preparing modified and/or truncated BChE molecules having selected properties, especially selective formation of monomers, are also described. Vectors and cells containing and/or expressing the nucleic acids are also disclosed.
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