APOPTOTIC CELL-MEDIATED TRANSFECTION OF MAMMALIAN CELLS WITH INTERFERING RNA

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United States of America Patent

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14137136

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Abstract

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Mammalian host cells for use in a cell-mediated tranfection process, which contain an RNAi molecule and an expression vector for a pro-apoptotic protein. The method includes inducing apoptotic cell (AC) death in mammalian cells that contain an RNAi molecule capable of downregulating a chosen target gene. Living cells expressing the target gene are then exposed to the ACs. The ACs are processed by the living cells, and the RNAi molecule in the ACs downregulates the expression of the target gene in living cells.

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Patent Owner(s)

Patent OwnerAddress
LOMA LINDA UNIVERSITYLOMA LINDA CALIFORNIA 92350

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Escher, Alan P Redlands, US 18 50
Li, Fengchun Loma Linda, US 13 41

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