Dielectrophoretic Tweezers as a Platform for Molecular Force Spectroscopy in a Highly Parallel Format
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United States of America Patent
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Aug 7, 2014
app pub date -
Aug 8, 2013
filing date -
Aug 8, 2012
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Abstract
Provided herein are methods of performing force spectroscopy, the methods comprising the steps of providing dielectrophoretic tweezers having at least one set of macroscopic electrodes, at least one of the electrodes having a microfabricated dielectric structure comprising a microwell; depositing force probes on a surface; binding the force probes to molecules on the surface; and applying voltage across set of macroscopic electrodes to thereby manipulate the molecules. Also provided are novel apparatus for performing force spectroscopy, the apparatus comprising dielectrophoretic tweezers having at least one set of macroscopic electrodes, at least one of the electrodes having a microfabricated dielectric structure comprising a microwell.
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