Method for the Production of Fluoromethyl Esters of Androstan-17 beta Carboxylic Acids
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United States of America Patent
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Issued Date -
Jul 17, 2014
app pub date -
May 25, 2012
filing date -
May 26, 2011
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Abandoned
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Abstract
Described herein are processes for the preparation of monofluoromethylated organic biologically active compounds, starting from protected intermediates and/or reagents to obtain compounds such as fluticasone propionate and fluticasone furoate, in presence of decarboxylating reagents XeF2 and BrF3, or using FCH2SH as a reagent.
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