Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
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United States of America Patent
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May 26, 2020
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Jul 17, 2014
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Jun 6, 2012
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Jun 7, 2011
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Abstract
The present invention features methods for treating or ameliorating tissue damage using intravenous administration of compositions that include stromal cell derived factor-1 (SDF-1) peptides or mutant SDF-1 peptides that have been mutated to make them resistant to protease digestion, but which retain chemoattractant activity. Systemic delivery, and specifically intravenous (“IV”) delivery, of SDF-1 and protease resistant SDF-1 mutants is very effective for the treatment of tissue damage.
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