Peripheral Administration of Proteins Including TGF-beta Superfamily Members for Treatment of Systemic Disorders and Disease

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United States of America Patent

APP PUB NO 20140187486A1
SERIAL NO

13945317

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the TGF-β superfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is BMP-7. The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the peripheral site of intravenous administration of the bioactive agent.

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Patent Owner(s)

Patent OwnerAddress
STRYKER CORPORATIONPORTAGE MI

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  • 2013 Application Filing Year
  • A61K Class
  • 12711 Applications Filed
  • 11051 Patents Issued To-Date
  • 86.95 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2013201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Goad, Mary Elizabeth Pecquet Andover, US 9 9
Haskell, Melissa M Uxbridge, US 5 8
Schrier, Denis Hopkinton, US 16 44
Wood, Susan A Dedham, US 17 839

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges1767499999127813872291511752101 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +0250500750100012501500175020002250250027503000325035003750400042504500475050005250

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