PRESELECTION OF SUBJECTS FOR THERAPEUTIC TREATMENT BASED ON HYPOXIC STATUS

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United States of America Patent

APP PUB NO 20140178366A1
SERIAL NO

14109543

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides methods for the preselection of a subject for therapeutic treatment with an agent based on modulated levels of hypoxia in cancerous cells in the subject. In one embodiment, the invention provides methods for the preselection of a subject for therapeutic treatment with an agent based on modulated levels of lactate dehydrogenase (LDH) in a cell, e.g., a cancerous cell. The invention also provides methods for treating cancer in a subject by administering an effective amount of an agent to the subject, wherein the subject has been selected based on a modulated level of hypoxia. The invention further provides kits to practice the methods of the invention.

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Patent Owner(s)

Patent OwnerAddress
SYNTA PHARMACEUTICALS CORPLEXINGTON MA 02421

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blackman, Ronald K Brookline, US 14 186
Vukovic, Vojo Winchester, US 13 69

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