Methods and compositions for gene-specific demethylation by DNA methyltransferase (DNMT)-RNA interaction

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United States of America Patent

PATENT NO 10941399
APP PUB NO 20140171492A1
SERIAL NO

14111971

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Abstract

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The present invention relates to chimeric RNA oligonucleotides that are single-stranded oligonucleotides. These compounds are capable of targeting particular genes and reducing DNA methyltransferase activity. Accordingly, these compounds are particularly useful in the treatment of disease associated with aberrant DNA methyltransferase activity, such as cancer or a genetic disorder.

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UNIVERSITA CATTOLICA DEL SACRO CUORELARGO AGOSTINO GEMELLI 1 MILANO 20123

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Di, Ruscio Annalisa Brookline, US 5 8
Ebralidze, Alexander K Brookline, US 5 8
Leone, Giuseppe Rome, IT 28 32
Tenen, Daniel G Jamaica Plain, US 7 25

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