METHYLATION SIGNATURE FOR REPLICATIVE SENESCENCE OF CELLS IN CULTURE

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United States of America Patent

APP PUB NO 20140170663A1
SERIAL NO

14236634

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Abstract

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A method for determining a replicative senescence status of a cell includes determining a methylation status of at least one CpG-dinucleotide within a region of at least one of about 50,000 bp upstream and downstream of at least one CpG-dinucleotide selected from the group consisting of GRM7-CpG-site #1, CASR-CpG-site #1, PRAMEF2-CpG-site #1, SELP-CpG-site #1, CASP14-CpG-site #1, and KRTAP13-3-CpG-site #1. The methylation status of each of the at least one CpG-dinucleotide determined is compared with a reference methylation status of the respective CpG-dinucleotide.

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Patent OwnerAddress
RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHENTEMPLERGRABEN 55 AACHEN 52062

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Inventor Name Address # of filed Patents Total Citations
Joussen, Sylvia Eschweiler, DE 1 0
Koch, Carmen Aachen, DE 1 0
Schellenberg, Anne Aachen, DE 1 0
Wagner, Wolfgang Aachen, DE 128 1676

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