Methods and Compositions for Treating Conditions of the Eye

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United States of America Patent

APP PUB NO 20140163451A1
SERIAL NO

13964510

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Abstract

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Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT method can be enhanced by combining the PDT with an anti-angiogenesis factor, for example, angiostatin or endostatin, or with an apoptosis-modulating factor. Furthermore, the selectivity and sensitivity of the PDT may be further enhanced by coupling a targeting moiety to the photosensitizer so as to target the photosensitizer to choroidal neovasculature.

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Patent Owner(s)

Patent OwnerAddress
MASSACHUSETTS EYE AND EAR INFIRMARYBOSTON MASSACHUSETTS 02114

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gragoudas, Evangelos S Lexington, US 38 703
Miller, Joan W Winchester, US 59 906
Renno, Reem Z Boston, US 7 89

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