Methods for detection and quantification of analytes in complex mixtures

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United States of America Patent

PATENT NO 9920380
SERIAL NO

13794299

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Abstract

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The invention provides a diverse population of uniquely labeled probes, containing about thirty or more target specific nucleic acid probes each attached to a unique label bound to a nucleic acid. Also provided is a method of producing a population of uniquely labeled nucleic acid probes. Also provided is a method of detecting a nucleic acid analyte. The method consists of (a) contacting a mixture of nucleic acid analytes under conditions sufficient for hybridization with a plurality of target specific nucleic acid probes each having a different specifier; (b) contacting the mixture under conditions sufficient for hybridization with a corresponding plurality of anti-genedigits each having a unique label, the plurality of anti-genedigits having a diversity sufficient to uniquely hybridize to genedigits within the specifiers, and (c) uniquely detecting a hybridized complex between one or more analytes in the mixture, a target specific probe, and an anti-genedigit.

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Patent Owner(s)

Patent OwnerAddress
THE INSTITUTE FOR SYSTEMS BIOLOGY1441 NORTH 34TH STREET SEATTLE WA 98103

International Classification(s)

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  • 2013 Application Filing Year
  • C12Q Class
  • 2617 Applications Filed
  • 2019 Patents Issued To-Date
  • 77.15 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2013201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dimitrov, Krassen M Seattle, US 6 182
Dunaway, Dwayne L Seattle, US 18 828

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Patent Citation Ranking

  • 0 Citation Count
  • C12Q Class
  • 0 % this patent is cited more than
  • 7 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges3285212917835231494333601 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +020040060080010001200140016001800200022002400260028003000320034003600

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