DENSITY-BASED METHOD OF COMPARING IMAGES AND DETECTION OF MORPHOLOGICAL CHANGES USING THE METHOD THEREOF

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United States of America Patent

APP PUB NO 20140161342A1
SERIAL NO

14233433

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Abstract

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A method of processing data for comparing at least two images using data processing elements, includes extracting a first sample of coordinate values (X1, . . . , Xn1) from at least one first image (Im1) and a second sample of coordinate values (Y1, . . . , Yn2) from at least one second image (Im2). A normal score value (Z) is then computed, with the processing elements, based on a density test statistic function ({circumflex over (T)}) applied on the first and second samples of coordinate values, wherein this density test statistic function has an asymptotic distribution, and a p-value, derived from the computed normal score value (Z), is compared (400) with a predetermined level of significance (α) in order to determine a similarity between the two images. The method can be used for determining the influence and assessing the cytotoxicity of a compound, monitoring a drug treatment, determining cellular morphology changes and the influence of an infection by pathogens.

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Patent Owner(s)

Patent OwnerAddress
INSTITUT CURIE75005 PARIS
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS75016 PARIS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Duong, Thanh Buu Paris, FR 1 1
Goud, Bruno Paris, FR 9 64
Schauer, Kristine Paris, FR 1 1

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