Bispecific Asymmetric Heterodimers Comprising Anti-CD3 Constructs
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United States of America Patent
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Jun 5, 2014
app pub date -
Jul 13, 2013
filing date -
Jul 13, 2012
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Abstract
Disclosed herein are isolated multi-specific heteromultimer constructs that bind to CD3 expressed on T-cells and to an antigen expressed on B-cells. The multi-specific heteromultimer constructs are capable of bridging T- and B-cells and mediating killing of B-cells. The multi-specific heteromultimer constructs are based on a heterodimeric Fc scaffold or on a segmented albumin scaffold. Also disclosed herein are multi-specific heteromultimer constructs that bind to HER2 and HER3.
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