CARBONIC ANHYDRASE INHIBITORS WITH ANTIMETASTATIC ACTIVITY
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United States of America Patent
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app pub date -
Nov 12, 2013
filing date -
Nov 28, 2010
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Abstract
Derivatized coumarin-based pharmaceutical compositions and methods to use them are provided. The compositions are characterized in that they inhibit the activity of tumor-related CAIX and CAXII to a greater degree than they inhibit the activity of CAI and CAII. The compositions can be used to suppress tumor growth and/or suppress tumor metastases in a mammal.
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