MONOCLONAL ANTIBODY TO HUMAN EPITHELIAL CELL ADHESION MOLECULE AND METHOD FOR DETECTING CIRCULATING TUMOR CELLS USING THE SAME
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United States of America Patent
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N/A
Issued Date -
May 22, 2014
app pub date -
Nov 20, 2013
filing date -
Nov 22, 2012
priority date (Note) -
Abandoned
status (Latency Note)
Importance
Abstract
An anti-EpCAM monoclonal antibody is provided which specifically recognizes an epitope different from the epitope which conventionally known anti-EpCAM monoclonal antibodies recognize (the N-terminal EGF-like domain). Also provided is a hybridoma which is capable of producing such monoclonal antibody, and a method for detecting CTC using such monoclonal antibody and a kit for detecting CTC, which is used for the method. The present application provides a monoclonal antibody to the human epithelial cell adhesion molecule (EpCAM) as a solution for the above problem, wherein the monoclonal antibody to the human epithelial cell adhesion molecule (EpCAM) specifically reacts with the CP region of the human epithelial cell adhesion molecule (EpCAM) and is produced by a hybridoma with accession No. NITE BP-1449. There are also provided a method for detecting circulating tumor cells using the above antibody and a kit for detecting circulating tumor cells, which is used for the method, and a hybridoma with accession No. NITE BP-1449.
First Claim
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