LINEAR DNA AMPLIFICATION
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United States of America Patent
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Issued Date -
May 22, 2014
app pub date -
May 4, 2012
filing date -
May 5, 2011
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Abandoned
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Abstract
The present invention provides materials and methods for DNA amplification, in particular linear amplification methods using RNA polymerase. These methods permit high-throughput sequencing of pictogram amounts of DNA and are of use in a range of applications including genome-wide profiling of transcription factors and epigenetic DNA and histone modifications, global transcript profiling, mapping of chromatin conformations, as well as for forensic use and archaeological studies.
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