Injectable Depot Compositions and Uses Thereof

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United States of America Patent

APP PUB NO 20140141086A1
SERIAL NO

14083289

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Abstract

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Injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having a miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patients body surface by injection.

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Patent Owner(s)

Patent OwnerAddress
DURECT CORPORATION10260 BUBB ROAD CUPERTINO CALIFORNIA 95014-4166 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Guohua Sunnyvale, US 140 4028
Houston, Paul R Hayward, US 33 1249
Kleiner, Lothar W Los Altos, US 94 1709

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