METHODS OF MODULATING SMYD3 FOR TREATMENT OF CANCER
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United States of America Patent
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Issued Date -
May 15, 2014
app pub date -
Apr 22, 2011
filing date -
Jul 1, 2005
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Abandoned
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Abstract
The present invention features a method for determining the methyltransferase activity of a polypeptide and screening for modulators of methyltransferase activity, more particularly for modulators of the methylation of retinoblastoma by SMYD3. The invention further provides a method or pharmaceutical composition for prevention or treating of colorectal cancer, hepatocellular carcinoma, bladder cancer and/or breast cancer using a modulator so identified.
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