CELLULAR HEMOGLOBIN A1C QUALITY CONTROLS
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United States of America Patent
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Issued Date -
May 15, 2014
app pub date -
Oct 24, 2013
filing date -
Nov 15, 2012
priority date (Note) -
Abandoned
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Abstract
Intact erythrocytes with selected and often elevated levels of hemoglobin A1c (HbA1c) for use as quality controls for HbA1c assays and assay instruments are prepared by hypotonic dialysis of erythrocytes from a healthy mammal to permeabilize the erythrocyte membranes, infusion of the permeabilized erythrocytes with hemoglobin A1c, and de-permeabilization of the infused erythrocytes. Quality controls of essentially any level of HbA1c can be prepared in this manner and once prepared will be useful for monitoring the entire assay procedure, including the lysis of the erythrocytes in a typical sample.
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