TCR Mimic Antibodies as Vascular Targeting Tools
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United States of America Patent
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Issued Date -
May 15, 2014
app pub date -
Nov 12, 2013
filing date -
Mar 24, 2011
priority date (Note) -
Abandoned
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Abstract
The present invention includes a method of delivering a therapeutic agent into and across an endothelial cell (EC) in a subject in need thereof, comprising: identifying a subject in need for treatment of a cancer in the brain; attaching to a TCR mimic an active agent to form a therapeutic agent; and administering to the subject the therapeutic agent in a pharmaceutically acceptable carrier, wherein the therapeutic agent effectively crosses the blood-central nervous system microvascular barrier.
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