PROCESS FOR OBTAINING RIVAROXABAN AND INTERMEDIATE THEREOF
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United States of America Patent
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Issued Date -
May 8, 2014
app pub date -
May 18, 2012
filing date -
May 20, 2011
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Abandoned
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Abstract
This invention relates to a procedure for obtaining a thiophene-2-carboxamide compound, specifically rivaroxaban, which comprises the (i) fragmentation of the N═C bond of a compound of formula 23 where R1 is selected among hydrogen, halogen, and (C1-C6)alkyl; and (ii) acylation of the resulting intermediate with 5-chloro-tiofen-2-carbonyl chloride in a solvent medium, in the presence of a base. The invention also relates to the compounds of formula 23 and their use in the obtention of rivaroxaban.
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